Impaired Wound-Healing, Local Eczema, and Chronic Inflammation Following Titanium Osteosynthesis in a Nickel and Cobalt-Allergic Patient: A Case Report and Review of the Literature

Peter Thomas, MD¹; Manfred Thomas, MD²; Burkhard Summer, PhD¹; Karin Dietrich, MD¹; Melanie Zauzig³; Erwin Steinhauser, PhD³; Veit Krenn, MD⁴; Hans Arnholdt, MD⁵; Michael J. Flaig, MD¹ 


The Journal of Bone & Joint Surgery, Volume 93, Issue 11


Patients known to develop allergic reactions to nickel (Ni), cobalt (Co), or chromium (Cr) often develop eczema in association with items of daily use such as jewelry, earrings, or watchbands. The overall sensitization rates to these metals may range between 1.1% (chromium) and 13% (nickel) in the general population, with further differences based on age and sex¹. Chromium-cobalt alloys and stainless steel are widely used as orthopaedic implants and may release nickel, chromium, or cobalt into the surrounding tissues as a consequence of either wear or corrosion². Some patients with a metal allergy may develop dermatitis in association with orthopaedic implants, and the prevalence of dermal sensitivity in patients with a joint replacement, particularly a failed implant, is higher than that in the general population³. Metal sensitivity rates to nickel, cobalt, or chromium may be as high as 43% in orthopaedic patients with well-functioning implants and as high as 71% in patients with poorly functioning implants³. In contrast, because of their excellent biocompatibility, titanium (Ti)-based materials are not considered to provoke allergic reactions. Our patient developed eczema and impaired wound-healing following the fixation of an ankle fracture with titanium-based implants. Histological analysis of the tissue around the implant demonstrated inflammation primarily with lymphocytes, and a contact allergy to nickel and cobalt was found in the absence of titanium hyperreactivity, raising the question of a prior unknown nickel exposure as the source of the complications. The patient was informed that data concerning this case would be submitted for publication, and she consented.


Investigation performed at the Department of Dermatology and Allergology, Ludwig-Maximilians-University Munich, Munich; the Department of Precision- and Micro-Engineering/Engineering Physics, Munich University of Applied Sciences, Munich; the Department of Foot Surgery, Hessingpark-Clinic, Augsburg; and the Institute of Pathology, Augsburg, Germany